Metrohm 763 PVC Thermomat Manual - Manual (Page 123)

4 Operation
763 PVC Thermomat
116
4.8 GLP
4.8.1 General information about GLP and validation
The requirements of GLP (Good Laboratory Practice) include a peri-
odic check of analytical measuring instruments with regard to their re-
producibility and accuracy using Standard Operating Procedures,
SOP. Under the title «Application Bulletin No. 278 – Validation of
Metrohm PVC Thermomats» an example of such a standard operat-
ing procedure for the 763 PVC Thermomat is available from Metrohm.
The operating software for the 763 PVC Thermomat contains prepared
GLP tests for temperature, conductivity and gas flow measurements.
The operator can determine whether and which tests are to be carried
out; in addition the intervals between the tests and the required accu-
racy can also be set down. If the GLP function is activated then each
result report will contain a remark stating whether the GLP test require-
ments have been fulfilled. Metrohm offers the 6.5616.000 GLP test set
as an option for carrying out the most important tests.
Further information on the subjects of QA, GLP and validation can also
be found in the brochure «Quality management with Metrohm»,
which is available from your local Metrohm agency.
Testing of the electronic and mechanical function groups of Metrohm
instruments can and should be performed as part of a regular service
by trained personnel of the manufacturing company (see section 5.1.1).
All Metrohm instruments are equipped with start-up-test routines which
check for perfect functioning of the relevant assemblies when the in-
strument is switched on. If no error message is displayed, it may be as-
sumed the instrument is operating without faults.
The Metrohm company also supplies its instruments with an integrated
diagnostic program which, in the case of possible malfunctions or faulty
behavior, allows the service technician to check the functioning of cer-
tain assemblies and localize the fault.